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18F-FDG Imaging by PET |
FLT: 18F-fluorothymidine PET using 11C- or 18F-labeled DNA precursors has a potential for specific imaging of proliferation in vivo. 11C-thymidine represents the native thymidine molecule and has been evaluated in preclinical and clinical studies . However, because of the rapid in vivo degradation and short half-life of 11C, this tracer was regarded as inappropriate for routine clinical use. In 1998, Shields et al. introduced 3'-deoxy-3'-18F-fluorothymidine (FLT) as a thymidine analog that is resistant to in vivo degradation and accumulates predominantly in proliferating tissues |
124Iodine Imaging by PET Radioiodine kinetics and, hence, LDpA of DTC metastases showed great
variability. For that reason, multiple 124I PET
investigations are required. The 5-point protocol is
certainly the most accurate among the approaches
investigated, but the adapted 24-96-h approach using 2 points
is an optimal dosimetry protocol when the clinical workload
is particularly heavy, reducing logistical and time demands
for patients and caregivers and clinical costs |
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